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KMID : 0385019990150030315
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 3 p.315 ~ p.324
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The Grading Scores of Aging, Reproductive Performance, Hematology, Serum Biochemistry and Urine Biochemistry of Senescence-Accelerated Mouse(SAM) with Age in KRICT Colony
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조규혁/Cho, Kyu Hyuk
양승돈/양경숙/유제권/이필수/송창우/한상섭/Yang, Sung Don/Yang, Kyung Sook/Yoo, Je Kwen/Lee, Phil Soo/Song, Chang Woo/Han, Sang Seop
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Abstract
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Animal models are very important tools for biomedical studies on gerontological research, various human diseases, and drug development. SAM (Senescence-Accelerated Mouse) wes originally developed at Kyoto University. SAM is useful marine model for the study of accelerated senescence. SAMP8 (defective learning and memory) and SAMR1 (control strain for SAM P series) have been maintained at KRICT breeding colony in SPF condition. In this study, we monitored the changes in grading scores of aging, reproductive performance, and physiological parameters (hematology, surum and urine biochemistry). The high grading scores of aging in SAMP8 was due to earlier onset of loss of passivity and reactivity, loss of skin glossiness, increased lordokyphosis of the spine with age as compared to the SAMR1. The reproductive performances (delivery rate, litter size, weaning rate) of SAM (R1, P8) were lower (or smaller) than AKR mice, the original strain which SAM derived from. SAMP8 showed higher serum concentration of Na^+, Cl^+, and ALP than SAMR1. However, hematology, WBC differential counts and urine biochemistry were in normal range, suggesting that SAM in our colony animals are in good health except for accelerated aging.
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KEYWORD
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